Martin Antibody Numbering
abYsis supports all major numbering systems. The Martin numbering scheme is based on Chothia and expands the approach to subsequently identified Framework regions.
Martin Details
In addition to indels in CDR-L1 and CDR-H1 that are considered by the Chothia scheme, the 'Martin' scheme considers the structurally correct locations for indels in the Framework regions.
In detail:
H82a,b,c is moved to the structurally correct location of H72a,b,c.
An indel site at L52 in CDR-L2 is introduced.
This approach also corresponds with the AHo numbering scheme.
In the scheme below, locations of deleted residues are indicated with ().
Numbering using the Kabat system is as follows:
Light chain
0 1 2 3 4 5 6 7 8 9
(10) 11 12 13 14 15 16 17 18 19
20 21 22 23 24 25 26 27 28 29
(30)
30A 30B 30C 30D 30E 30F
31 32 33 34 35 36 37 38 39
40
40A (41) 42 43 44 45 46 47 48 49
50 51 (52)
52A 52B 52C 52D 52E
53 54 55 56 57 58 59
60 61 62 63 64 65 66 67 (68)
68A 68B 68C 68D 68E 68F 68G 68H 69
70 71 72 73 74 75 76 77 78 79
80 81 82 83 84 85 86 87 88 89
90 91 92 93 94 (95)
95A 95B 95C 95D 95E 95F 96 97 98 99
100 101 102 103 104 105 106 107
107A 108 109
110
Heavy chain
0 1 2 3 4 5 6 7 (8)
8A 8B 8C 8D 9
10 11 12 13 14 15 16 17 18 19
20 21 22 23 24 25 26 27 28 29
30 (31)
31A 31B
32 33 34 35 36 37 38 39
40 41 (42) 43 44 45 46 47 48 49
50 51 (52)
52A 52B 52C 53 54 55 56 57 58 59
60 61 62 63 64 65 66 67 68 69
70 71 72
72A 72B 72C 73 74 75 76 77 78 79
80 81 82 83 84 85 86 87 88 89
90 91 92 93 94 95 96 97 98 99
(100)
100A 100B 100C 100D 100E 100F 100G 100H 100I 100J
100K 101 102 103 104 105 106 107 108 109
110 111 112 113For more information, visit the web site of our collaborator Professor Andrew Martin, from which the information here was adapted: www.bioinf.org.uk/abs